Trifluopérazine


Trifluopérazine
Trifluopérazine
Trifluopérazine
Général
Nom IUPAC 10-[3-(4-méthylpipérazin-1-yl)propyl]-2-(trifluorométhyl)-10H-phénothiazine
No CAS 117-89-5
No EINECS 204-219-4
Code ATC N05AB06
DrugBank DB00831
PubChem 5566
ChEBI 45951
SMILES
InChI
Propriétés chimiques
Formule brute C21H24F3N3S  [Isomères]
Masse molaire[1] 407,496 ± 0,024 g·mol-1
C 61,9 %, H 5,94 %, F 13,99 %, N 10,31 %, S 7,87 %,
Propriétés physiques
Solubilité 12,2 mg·l-1 (eau,24 °C) [2]
Écotoxicologie
DL50 1,35 g·kg-1 (souris, oral)
29 mg·kg-1 (souris, i.v.)
120 mg·kg-1 (souris, i.p.) [2]
LogP 5,03 [2]
Données pharmacocinétiques
Métabolisme hépatique
Demi-vie d’élim. 10-20 heures
Unités du SI & CNTP, sauf indication contraire.

La trifluopérazine (Terfluzine) est un antipsychotique typique de la classe des phénothiazines.

Notes et références

  1. Masse molaire calculée d’après Atomic weights of the elements 2007 sur www.chem.qmul.ac.uk.
  2. a, b et c (en) « Trifluoperazine » sur ChemIDplus, consulté le 31 juillet 2009

Liens externes


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Contenu soumis à la licence CC-BY-SA. Source : Article Trifluopérazine de Wikipédia en français (auteurs)

Regardez d'autres dictionnaires:

  • Trifluoperazine — Systematic (IUPAC) name 10 [3 (4 methylpiperazin 1 yl)propyl] 2 (trifluoromethyl) 10H phenothiazine Clinical data AHFS/ …   Wikipedia

  • trifluoperazine — noun Etymology: tri + fluor + piperazine Date: circa 1957 a phenothiazine tranquilizer C21H24F3N3S chiefly used to treat psychotic conditions and especially schizophrenia …   New Collegiate Dictionary

  • trifluoperazine — (= TFP; trifluperazine; Stellazine) Antipsychotic drug that inhibits calmodulin at levels just below those at which it kills cells …   Dictionary of molecular biology

  • trifluoperazine — /truy flooh euh per euh zeen /, n. Pharm. a compound, C21H24F3N3S, used as an antipsychotic. [1955 60; TRI + FLUO + (PI)PERAZINE] * * * …   Universalium

  • trifluoperazine — noun An antipsychotic drug of the phenothiazine group …   Wiktionary

  • trifluoperazine — tri·fluo·per·a·zine .trī .flü ō per ə .zēn, zən n a phenothiazine tranquilizer C21H24F3N3S used esp. to treat psychotic conditions and esp. schizophrenia see STELAZINE * * * n. an antipsychotic drug (a phenothiazine) with uses and effects similar …   Medical dictionary

  • trifluoperazine — n. chemical compound used as a sedative …   English contemporary dictionary

  • trifluoperazine — tri·fluo·per·a·zine …   English syllables

  • trifluoperazine — n. an antipsychotic drug (a phenothiazine) used in the treatment of schizophrenia and other psychoses, severe anxiety, and severe nausea and vomiting. It is taken by mouth; common side effects include drowsiness, dryness of mouth, dizziness,… …   The new mediacal dictionary

  • trifluoperazine — tri•flu•o•per•a•zine [[t]traɪˌflu əˈpɛr əˌzin[/t]] n. pha a compound, C21H24F3N3used as an antipsychotic drug • Etymology: 1955–60; tri +fluo , var. of fluoro + (pi) perazine …   From formal English to slang


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