Ésoméprazole
- Ésoméprazole
-
| Ésoméprazole |
 |
| Général |
| Nom IUPAC |
(S)-6-méthoxy-2-[(4-méthoxy-3,5-diméthylpyridin-2-yl)méthylsulfinyl]-1H-benzimidazole |
| No CAS |
119141-88-7 |
| Code ATC |
A02BC05 |
| DrugBank |
APRD00363 |
| PubChem |
4594 |
| SMILES |
c12c([nH]c(n1)[S@@](Cc1c(c(c(C)cn1)OC)C)=O)ccc(c2)OC
PubChem, Vue 3D
|
| InChI |
InChI : Vue 3D
InChI=1S/C17H19N3O3S/c1-10-8-18-15(11(2)16(10)23-4)9-24(21)17-19-13-6-5-12(22-3)7-14(13)20-17/h5-8H,9H2,1-4H3,(H,19,20)
InChIKey :
SUBDBMMJDZJVOS-UHFFFAOYSA-N
|
| Propriétés chimiques |
| Formule brute |
C17H19N3O3S [Isomères]
|
| Masse molaire[1] |
345,416 ± 0,021 g·mol-1
C 59,11 %, H 5,54 %, N 12,17 %, O 13,9 %, S 9,28 %,
|
| Données pharmacocinétiques |
| Biodisponibilité |
50 à 90% |
| Métabolisme |
Hépatique (CYP2C19, CYP3A4) |
| Demi-vie d’élim. |
1 à 1H30 |
| Excrétion |
80% rénale
20% fécale |
|
Unités du SI & CNTP, sauf indication contraire.
|
L'ésoméprazole est un antisécrétoire gastrique inhibiteur de la pompe à protons, antiulcéreux.
Notes et références
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