Locus control region

Locus control region

Locus control region

La Locus control region est une séquence d'ADN qui va stimuler la transcription d'ADN en fonction du contexte moléculaire de la cellule (lié au nombre de copies d'ARNm de ce gène déjà transcrite, permet le maintien d'un nombre suffisant de copies d'ARN)

La LCr a été identifié il y a plus de 20 ans. Lors d'une étude sur des souris transgéniques, il a été déterminé que la LCR était requise pour la régulation de l'expression des béta-globulines[1]. Il existe plusieurs modèles décrivant comment la LCR est capable d'avoir un effet à distance sur la transcription.

Références

  1. Mark B. Gerstein et al., "What is a gene, post-ENCODE? History and updated definition," Genome Research 17(6) (2007): 669-681
  • Portail de la biochimie Portail de la biochimie
  • Portail de la biologie cellulaire et moléculaire Portail de la biologie cellulaire et moléculaire
Ce document provient de « Locus control region ».

Wikimedia Foundation. 2010.

Contenu soumis à la licence CC-BY-SA. Source : Article Locus control region de Wikipédia en français (auteurs)

См. также в других словарях:

  • Locus control region — Locus control regions (LCR) are defined by their ability to enhance the expression of linked genes to physiological levels in a tissue specific and copy number dependent manner at ectopic chromatin sites. The concept that developmental and cell… …   Wikipedia

  • locus control region — (= control region; LCR) Region of DNA which contains the promoters and enhancers that regulate the expression of a particular gene. Often taken to be a single region 0 2kb upstream of the transcriptional start site, although there are probably… …   Dictionary of molecular biology

  • locus control region — (LCR) a segment of DNA situated apart from a structural gene or cluster of genes but acting in cis to increase the transcriptional activity of the gene or cluster, probably by opening and remodeling chromatin structure …   Medical dictionary

  • Locus — The place, in Latin.. In genetics, a locus is the place a gene occupies on a chromosome. One locus, two loci. * * * 1. A place; usually, a specific site. 2. The position that a gene occupies on a chromosome. 3. The position of a point, as defined …   Medical dictionary

  • Locus ceruleus — Infobox Brain Name = Locus ceruleus Latin = locus caeruleus GraySubject = 187 GrayPage = 778 Caption = Rhomboid fossa. (Locus ceruleus not labeled, but region is very near colliculus facialis, which is labeled at center left.) Caption2 = IsPartOf …   Wikipedia

  • Human β-globin locus — The human β globin locus is composed of five genes located on a short region of chromosome 11, responsible for the creation of the beta parts (roughly half) of the oxygen transport protein Hemoglobin. This locus contains not only the beta globin… …   Wikipedia

  • Nonlinear control — is the area of control engineering specifically involved with systems that are nonlinear, time variant, or both. Many well established analysis and design techniques exist for LTI systems (e.g., root locus, Bode plot, Nyquist criterion, state… …   Wikipedia

  • Quantitative Trait Locus — Darstellung eines QTL für Osteoporose auf dem menschlichen Chromosom 20 (Quelle: PLoS Biology, 2003) Als Quantitative Trait Locus (abgekürzt QTL, Mehrzahl Quantitative Trait Loci, deutsch: Region eines quantitativen Merkmals) wird in der Genetik… …   Deutsch Wikipedia

  • LCRB — locus control region beta …   Medical dictionary

  • LCRB — • locus control region beta …   Dictionary of medical acronyms & abbreviations


Поделиться ссылкой на выделенное

Прямая ссылка:
Нажмите правой клавишей мыши и выберите «Копировать ссылку»