Fluphenazine

Fluphenazine

Fluphénazine

Fluphénazine
Fluphénazine
Général
Nom IUPAC 2-[4-[3-[2-(trifluoromethyl)-
10H-phenothiazin-10-yl]propyl]-
piperazin-1-yl]ethanol
No CAS 69-23-8
No EINECS 200-702-9
Code ATC N05AB02
DrugBank APRD00633
PubChem 3372
Propriétés chimiques
Formule brute C22H26F3N3OS
Masse molaire 437,522 gmol-1
C 60,39 %, H 5,99 %, F 13,03 %, N 9,6 %, O 3,66 %, S 7,33 %,
Propriétés physiques
T° fusion <25 °C[1]
Pression de vapeur saturante 1.02E-12 mmHg à 25 °C[1]
Écotoxicologie
DL50 (souris, oral, 220 mg/kg)[1]
Données pharmacocinétiques
Biodisponibilité 40 à 50%
Métabolisme hépatique
Demi-vie d’élim. 15 à 30 heures
Excrétion bile et fèces
Considérations thérapeutiques
Voie d’administration orale[2], intramusculaire[2]
Unités du SI & CNTP, sauf indication contraire.

La fluphénazine (Modecate, Moditen) est un antipsychotique typique.

Notes et références

  1. a , b  et c (en) « Fluphénazine » sur ChemIDplus, consulté le 4 août 2009
  2. a  et b (en) « Fluphénazine » sur DrugBank, consulté le 4 août 2009
  • Portail de la chimie Portail de la chimie
  • Portail de la médecine Portail de la médecine
  • Portail de la pharmacie Portail de la pharmacie
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